DIAGNOSTIC AND THERAPEUTIC PROBLEMS OF ACUTE RENAL FAILURE IN CHILDHOOD

Acute renal failure (ACR) is a clinical-biological syndrome of sudden rapidly advancing, commonly reversible damage of renal function when a normal body homeostasis cannot be maintained. In the Department of Paediatrics, Medical University of Varna, 18 children with ACR were treated. The most common reasons for the ACR were the following: acute glomerulonephritis, haemolytic-uraemic syndrome, and severe malformations of the urinary tract. Blood urea, creatinine, ionogram,acid-base balance, and diuresis were dynamically monitored in all the children. Therapeutic behaviour was directed towards the correction of the dyselectrolytaemia and acid-alkaline profile. The elevated lethality rate still persisted. Three patients deceased

Survey the opinion and interest of students-pedagogues to the sport animation practice in an educational environment

The modern, dynamic and high-tech world sets new challenges for the man as a social and biological being. Lowering of the motor activity of people is a general phenomenon, leading to a number of adverse health and social problems, especially among the younger generation. This article introduces the problem with insufficient amount of motor activity, realized in the teaching forms on physical education at school age, and studies the interests of students-educators to the subject "Sport animation in the educational environment" in search of additional forms of sports activities for ignoring hypodinamics and its consequences

Synthesis of Improved Catalytic Materials for High-Temperature Water-gas Shift Reaction

In this investigation, we report the preparation and characterization of Co-, Cu- and Mn-substituted iron oxide catalytic materials supported on activated carbon. Co-precipitation method and low temperature treatment were used for their synthesis. The influence of chemical composition, stoichiometry, particle size and dispersity on their catalytic activity was studied. Samples were characterized in all stages of their co-precipitation, heating and spend samples after catalytic tests. The obtained results from room and low temperature Mössbauer spectroscopy were combined with analysis of powder X-ray diffraction patterns (XRD). They revealed the preparation of nano-sized iron oxide materials supported on activated carbon. Relaxation phenomena were registered also for the supported phases. The catalytic performance in the water-gas shift reaction was studied. The activity order was as follows: Cu0.5Fe2.5O4 > Co0.5Fe2.5O4 > Mn0.5Fe2.5O4. Catalytic tests demonstrated very promising results and potential application of studied samples due to their cost-effective composition

Одонтогенные абсцессы в челюстно-лицевой области у детей до 3-x летнего возраста: клиническое изучение воспалительных процессов одонтогенного происхождения 20 случаев в Болгарии

Introduction: Inflammatory processes of odontogenic origin in the maxillo-facial area are rare in children less than 3 years of age. Aim: The aim of this study was to present the structure and specific characteristics of odontogenic inflammatory processes in the maxillofacial area in children less than 3 years of age. Material and methods: Data was collected from patient’s medical files from the Clinic of Maxillofacial Surgery at “St. George” University Hospital in Plovdiv, Bulgaria between January 1996 and April 2008. Data processing was performed with software SPSS 11.0. Results: Inflammatory processes were mainly in the maxilla rather than the mandible (1/0.05). Surgical treatment was etiological and included intraoral incision (all patients), extraction of the deciduous tooth that caused the inflammation (in 95% of the patients), or conservative dental medication (in 5% of the patients). Operative treatment was under general anesthesia (in 80% of the patients), local anesthesia with premedication (in 5% of the patients), or local anesthesia (in 15% of the patients). On average 2.3 teeth per patient were extracted. The microorganisms most frequently found were E. coli, Str. α-haemol., Enterococcus. Cephalosporins were most frequently applied. The patients spent in a hospital an average of 3.3 days. Conclusion: Odontogenic abscesses and phlegmons are found in early childhood (less than 3 years of age), even though the denture is still forming; and there is a tendency of a rise in their frequency.Одонтогенные абсцессы в челюстно-лицевой области у детей до 3-x летнего возраста: клиническое изучение воспалительных процессов одонтогенного происхождения 20 случаев в Болгарии. Введение: Воспалительные процессы одонтогенного происхождения челюстно-лицевой области редко встречаются у детей 3 лет. Цель: Oписание структуры и характерных клинических признаков одонтогенных воспалительных процессов челюстно-лицевой области у детей младше 3-x лет. Материал и методы: Были собраны данные медицинских карт пациентов Клиники Челюстно-лицевой хирургии “St. George” в Университетской больнице г. Пловдив, Болгария, в период с января 1996 года по апрель 2008 года. Обработка данных проводилась с помощью программы SPSS 11.0. Результаты: Воспалительные процессы в основном были выявлены в верхней челюсти, а не в нижней (1/0.05). Хирургическое лечение являлось этиологическим методом и включало внутриротовой разрез (все пациенты), экстракцию больных зубов, которые вызвали воспаление (у 95% пациентов) или консервативное медикаментозное лечение (у 5% пациентов). Оперативное лечение было проведено под общей анестезией (у 80% пациентов), местной анестезией с премедикацией (у 5% больных), или местной анестезией (у 15% пациентов). В среднем были удалены 2, 3 зуба на одного пациента. Наиболее часто встречающиеся микроорганизмы были E. coli, Str. α-haemol., Enterococcus. Цефалоспорины – наиболее часто применяемые антибиотики. Число дней, проведенных в больнице, составляло в среднем 3,3 дня. Вывод: Одонтогенные абсцессы и флегмоны выявляются в раннем детском возрасте (у детей менее 3 лет), несмотря на развитие зубной ткани. И это является тенденцией роста их частоты

Different Approaches to Community Evolution Prediction in Blogosphere

Predicting the future direction of community evolution is a problem with high theoretical and practical significance. It allows to determine which characteristics describing communities have importance from the point of view of their future behaviour. Knowledge about the probable future career of the community aids in the decision concerning investing in contact with members of a given community and carrying out actions to achieve a key position in it. It also allows to determine effective ways of forming opinions or to protect group participants against such activities. In the paper, a new approach to group identification and prediction of future events is presented together with the comparison to existing method. Performed experiments prove a high quality of prediction results. Comparison to previous studies shows that using many measures to describe the group profile, and in consequence as a classifier input, can improve predictions.Comment: SNAA2013 at ASONAM2013 IEEE Computer Societ

Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.

BACKGROUND: Amplification of aurora kinase A (AK-A) overrides the mitotic spindle assembly checkpoint, inducing resistance to taxanes. RNA interference targeting AK-A in human pancreatic cancer cell lines enhanced taxane chemosensitivity. In this study, a novel AK-A inhibitor, CYC3, was investigated in pancreatic cancer cell lines, in combination with paclitaxel. METHODS: Western blot, flow cytometry and immunostaining were used to investigate the specificity of CYC3. Sulforhodamine B staining, time-lapse microscopy and colony-formation assays were employed to evaluate the cytotoxic effect of CYC3 and paclitaxel. Human colony-forming unit of granulocyte and macrophage (CFU-GM) cells were used to compare the effect in tumour and normal tissue. RESULTS: CYC3 was shown to be a specific AK-A inhibitor. Three nanomolar paclitaxel (growth inhibition 50% (GI(50)) 3 nM in PANC-1, 5.1 nM in MIA PaCa-2) in combination with 1 μM CYC3 (GI(50) 1.1 μM in MIA PaCa2 and 2 μM in PANC-1) was synergistic in inhibiting pancreatic cell growth and causing mitotic arrest, achieving similar effects to 10-fold higher concentrations of paclitaxel (30 nM). In CFU-GM cells, the effect of the combination was simply additive, displaying significantly less myelotoxicity compared with high concentrations of paclitaxel (30 nM; 60-70% vs 100% inhibition). CONCLUSION: The combination of lower doses of paclitaxel and CYC3 merits further investigation with the potential for an improved therapeutic index in vivo

WhiteHaul: An Efficient Spectrum Aggregation System for Low-Cost and High Capacity Backhaul over White Spaces

We address the challenge of backhaul connectivity for rural and developing regions, which is essential for universal fixed/mobile Internet access. To this end, we propose to exploit the TV white space (TVWS) spectrum for its attractive properties: low cost, abundance in under-served regions and favorable propagation characteristics. Specifically, we propose a system called WhiteHaul for the efficient aggregation of the TVWS spectrum tailored for the backhaul use case. At the core of WhiteHaul are two key innovations: (i) a TVWS conversion substrate that can efficiently handle multiple non-contiguous chunks of TVWS spectrum using multiple low cost 802.11n/ac cards but with a single antenna; (ii) novel use of MPTCP as a link-level tunnel abstraction and its use for efficiently aggregating multiple chunks of the TVWS spectrum via a novel uncoupled, cross-layer congestion control algorithm. Through extensive evaluations using a prototype implementation of WhiteHaul, we show that: (a) WhiteHaul can aggregate almost the whole of TV band with 3 interfaces and achieve nearly 600Mbps TCP throughput; (b) the WhiteHaul MPTCP congestion control algorithm provides an order of magnitude improvement over state of the art algorithms for typical TVWS backhaul links. We also present additional measurement and simulation based results to evaluate other aspects of the WhiteHaul design

Complete Experimental Structure Determination of the p(3x2)pg Phase of Glycine on Cu{110}

We present a quantitative low energy electron diffraction (LEED) surface-crystallograpic study of the complete adsorption geometry of glycine adsorbed on Cu{110} in the ordered p(3×2) phase. The glycine molecules form bonds to the surface through the N atoms of the amino group and the two O atoms of the de-protonated carboxylate group, each with separate Cu atoms such that every Cu atom in the first layer is involved in a bond. Laterally, N atoms are nearest to the atop site (displacement 0.41 Å). The O atoms are asymmetrically displaced from the atop site by 0.54 Å and 1.18 Å with two very different O-Cu bond lengths of 1.93 Å and 2.18 Å. The atom positions of the upper-most Cu layers show small relaxations within 0.07 Å of the bulk-truncated surface geometry. The unit cell of the adsorbate layer consists of two glycine molecules, which are related by a glide-line symmetry operation. This study clearly shows that a significant coverage of adsorbate structures without this glide-line symmetry must be rejected, both on the grounds of the energy dependence of the spot intensities (LEED-IV curves) and of systematic absences in the LEED pattern